Manchester City will travel across town to Manchester United in another epic Manchester Derby that will play a huge role in deciding this year's title race and battle for the top four.
Louis Van Gaal's men are currently third on the Premier League table, winning five of their previous six matches and Manchester City are fourth, losing three of their last six and struggling to find their best form.
United have won ten of their previous 11 home matches in the Premier League and are displaying their best form this season.
Aguero Taunts United Ahead Of Manchester Derby
City, meanwhile, have won all of their last four matches against Manchester United in all competitions, but have lost their last three matches away from home.
In the previous six matches between the two teams, Manchester United have only one win to City's five, with the citizens scoring 13 goals and the Red Devils managing only five.
In team news, Manchester United will be without the suspended Jonny Evans, while Chris Smalling and James Wilson are doubts because of their respective injuries.
For City, Wilfried Bony is missing through an injury and Vincent Kompany remains a doubt, however Pablo Zabaleta's return to right back will be a major boost for Manuel Pellegrini's men.
Here is how the teams will line-up:
Manchester United: De Gea, Valencia, Smalling, Jones, Blind, Carrick, Fellaini, Herrera, Mata, Young, Rooney
Manchester City: Hart, Zabaleta, Kompany (C), Demichelis, Clichy, Fernandinho, Toure, Navas, Milner, Silva, Aguero
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