The four South African teams playing in the CAF Champions League and Confederation Cup will travel over 18,750kms between them.
Read: CAF Champions League News
Kaizer Chiefs and Mamelodi Sundowns travel to Comoros and Zimbabwe respectively to take on their first CCL opponents, while Bidvest Wits and Ajax Cape Town head to Seychelles and Angola to get their CCC campaigns underway.
Wits, who face LightStars FC, have the longest distance to travel for their game this weekend, while Sundowns are heading just up the road to South Africa's neighbours, Chicken Inn, in Bulawayo.
South Africans Preliminary Round Distances
Wits - 3822km to Praslin, 7644km round-trip.
Ajax - 2966km to Dundu, 5932km round-trip.
Chiefs - 2276km to Moroni, 4552km round-trip.
Sundowns - 623km to Bulawayo, 1246 round-trip.
All four sides will be eager to make sure that they get a good away result this weekend before hosting their opponents in Mzansi at the end of the month, with away goals possibly proving crucial with regards to who wins each tie.
Read: CAF Confederation Cup News
Chiefs, Sundowns, Wits and Ajax all depart for their respective ties over the course of the day, and will then return in time for next week's Absa Premiership clashes.