All focus this weekend will be on Bafana Bafana as South Africa take on Algeria at the Orlando Stadium. We preview the international friendly, as well as some top-class European clashes.
In the English Premier League, Arsenal welcome Manchester City to the Emirates Stadium, while Manchester United host Liverpool at Old Trafford. Who is your money on? Will both Manchester-based clubs come out on top?
Other games in England see Queens Park Rangers up against Tottenham Hotspur in the EPL and Wolves against Blackburn Rovers in the English Championship.
In Portugal, we preview the top of the table clash between Benfica and Porto. In what is arguably the biggest game in Portuguese football, who is your money on?
If you are a betting person, here are tips ahead of the weekend's action brought to you by Soccer 6 and guest predictor, Maccabi Haifa striker, Dino Ndlovu.
For more info on these and other fixtures, go to the Soccer 6 website here or the Soccer 6 mobi-site here!
WOLVES V BLACKBURN ROVERS
League position: Wolves 18th and Rovers 13th (both in English Championship)
Useful facts: After relegation from the English Premiership, Wolves and Blackburn had hoped to bounce right back with some of the quality they had in their squad. It hasn't worked out that way for both teams who now languish in the middle to lower reaches of the Championship table.
Dino Ndlovu: Wolves home win.
QUEENS PARK RANGERS V TOTTENHAM HOTSPUR
League position: QPR 20th and Spurs 3rd
Useful facts: QPR will have taken great hope from their surprise away win over Chelsea recently. Harry Redknapp is already proving to be a miracle worker in White City. This means an in-form Spurs can't expect to have it all their own way at Loftus Road.
Dino Ndlovu: I'll go for a draw.
SOUTH AFRICA V ALGERIA
Fifa ranking: South Africa 84th and Algeria 19th
Useful facts: In what could be an invaluable preparation match for the upcoming Afcon, Gordon Igesund will be trying out some of his new combinations against the highly-ranked Algerians. What is in Bafana's favour is that the Desert Warriors sometimes struggle away from home.
Dino Ndlovu: Ha, ha! Bafana win!
MANCHESTER UNITED V LIVERPOOL
League position: United 1st and Liverpool 8th
Useful facts: United have been producing some tremendous attacking football and appear to be well on the way to yet another league title triumph. Liverpool are still a bit hit and miss under Brendan Rodgers, the Reds recently scraped through in the FA Cup against Conference outfit, Mansfield Town.
Dino Ndlovu: Win for United at Old Trafford.
ARSENAL V MANCHESTER CITY
League position: Arsenal 6th and City 2nd
Useful facts: Arsenal continue to show flashes of excellent passing football combined with moments of abject defending. This means City will fancy their chances at the Emirates Stadium.
Dino Ndlovu: I'll go for a high-scoring draw.
BENFICA V PORTO
League position: Benfica 1st and Porto 2nd
Useful facts: Benfica and Porto are fighting it out in Portugal at the top of the Primeira standings. Benfica have won seven games in a row at the Estadio da Luz. Porto will have to show significant improvement on their travels if they hope to come away with the spoils.
Dino Ndlovu: Porto away win.