Borussia Dortmund squandered a two-goal lead as they suffered their first defeat of the campaign in a five-goal thriller against Werder Bremen at Signal Iduna Park.
Julian Brandt got the breakthrough for Dortmund on the stroke of half-time and Raphael Guerreiro doubled their lead with 13 minutes remaining.
Lee Buchanan pulled a goal back for Bremen in the last minute and Niklas Schmidt levelled matters in stoppages.
Oliver Burke snatched the winner for the visitors in the tail end of added time
Bayer Leverkusen suffered their third straight defeat after they were thrashed 3-0 by Hoffenheim at BayArena.
Christoph Baumgartner gave Hoffenheim an early lead and Andrej Kramaric doubled their lead ten minutes before the half-time break.
Robert Skov thought he had made it 3-0 for the visitors just before the break but the goal was chalked off by the Video Assistant Referee (VAR) for offside in the build-up.
Georginio Rutter eventually put the game to bed for Hoffenheim in the last 12 minutes.
Both Wolfsburg and Schalke remained winless after they played to a goalless draw at Volkswagen Arena.
Simon Terodde had a big opportunity to give Schalke the lead from the penalty spot on the stroke of half-time but his spot-kick was saved by goalkeeper Koen Casteels.
Joshua Guilavogui found the back of the net for Wolfsburg on 66 minutes but his effort was disallowed by the Video Assistant Referee (VAR) for offside.
Mainz picked up their second victory of the season after edging Augsburg 2-1 at WWK Arena.
Karim Onisiwo broke the deadlock for Mainz on the half-hour mark but Ermedin Demirovic levelled matters just four minutes later.
Aaron Martin had a big chance to restore the lead for the visitors from the penalty spot just after the hour-mark but his spot-kick was saved by goalkeeper Rafal Gikiewicz.
Jae-Sung Lee eventually snatched the winner for Mainz in stoppage time.
Freiburg clinched their second win of the campaign after edging Stuttgart 1-0 at Mercedes-Benz Arena.
Vincenzo Grifo's early opener was enough to hand Freiburg all the three points.