Portugal cruised to victory in the absence of Cristiano Ronaldo after defeating Sweden 3-0 on Wednesday evening.
The European champions were without the services of Ronaldo, who had tested positive for the coronavirus on Tuesday.
Ronaldo's absence did not have a major impact as Selecao opened the scoring on 21 minutes through Manchester City Bernardo Silva, with Diogo Jota playing the final pass.
Jota registered a goal to go with his assist just before the halftime break to extend Portugal's advantage to 2-0.
The Reds star managed to complete his brace in the 72nd minute to make it 3-0 and send the defending champions to of Group 3 in League A.
France got back to winning ways in Group 3 with a 2-1 triumph over Croatia on Wednesday night.
Olivier Giroud and Paul Pogba were only named on the bench as Anthony Martial and Steven Nzonzi got starts for the 2018 World Cup winners.
Antoine Griezmann got the hosts off to the perfect start after opening the scoring in the eighth minute.
The hosts had to wait until the 64th minute to restore parity after Nikola Vlasic fired past Hugo Lloris for the equaliser.
However, it was the world champions who had the final say as Kylian Mbappe found the winning goal in the 79th minute to send his second.