Paris Saint-Germain finished their group stage campaign five points clear at the top after crushing Galatasaray 5-0 at Parc des Princes.
Neymar, Kylian Mbappe, Mauro Icardi, Pablo Sarabia and Edinson Cavani were all on target for the Ligue 1 giants, as Thomas Tuchel's charges finished with 16 points at the top of the section, while the Turkish giants ended bottom with two points.
Bayern Munich maintained their perfect campaign in Group B after thrashing Tottenham Hotspur 3-1 at Allianz Arena.
Kingsley Coman, Thomas Muller and Philippe Coutinho all netted for the hosts while Ryan Sessegnon scored what proved to be a consolation goal for Jose Mourinho's charges.
Olympiakos Piraeus sealed a place in the round of 32 of the UEFA Europa League after netting late to sink Red Star Belgrade 1-0 at Stadio Georgios Karaiskaki.
Youssef El-Arabi netted a penalty for Olympiakos three minutes before time to seal three points and a place in the UEFA Europa League, as they finished third in Group B with four points, one point above Red Star, who finished bottom.
Manchester City finished as group winners after thumping Dinamo Zagreb 4-1 in Zagreb in the early encounters.
Gabriel Jesus bagged a hat-trick and Phil Foden also got on the score-sheet after Dinamo had taken an early lead through Daniel Omo.
Atalanta made history after securing a spot in the round 16 after defeating Shakhtar Donetsk in their final game.
Timoty Castagne and Mario Pasalic netted in the second half to secure qualification for the Serie A side on a historic night
Serie A champions Juventus left it late to sink Bayer Leverkusen 2-0 to secure top spot in the group.
After a goalless first stanza, Cristiano Ronaldo and Gonzalo Higuain netted in the last 15 minutes to confirm top place finish in Group D, while Bayer had to settle for a place in the UEFA Europa League after finishing third.
Atletico Madrid went through to the last 16 after a 2-0 win over Lokomotiv Moscow at Estadio Wanda Metroplitano.
Joao Felix netted a goal in each half to seal second place in Group D for Diego Simeone's men, while Lokomotiv dropped out of the tournament after finishing bottom with three points.
