Manchester United maintained top spot in Group H after thrashing Istanbul Basaksehir 4-1 at Old Trafford.
Edinson Cavani was handed his first start along with Donny van de Beek while Paul Pogba missed out once again.
The hosts got off to the perfect start when Bruno Fernandes opened the scoring with a stunning strike from the edge before he doubled the lead in the 19th minute after a howler from Basaksehir Mert Günok.
The Red Devils got a third goal 10 minutes before the break when Marcus Rashford converted a penalty after he was fouled in the box.
Deniz Turuc reduced the deficit for the visitors midway through second half, but Daniel James got the fourth goal late in the half.
Paris Saint-Germain moved up to second spot in Group H with a 1-0 win over RB Leipzig in the French capital.
Neymar's penalty in the 11th minute was enough to seal three points for the French champions.
Borussia Dortmund grabbed top spot in the group after cruising to a 3-0 win over Club Brugge.
Erling Haaland opened the scoring on 18 minutes before Jadon Sancho made it 2-0 with a delightful free-kick.
Haaland wrapped up proceedings with for the Bundesliga in the 60th minute to complete his brace.
Lazio registered a 3-1 win over Zenit St Petersburg to move up to second spot in Group F on Tuesday night.
Ciro Immobile bagged a brace while Marco Parolo also netted for the hosts.
Artem Dzyuba scored the consolation for the Russian outfit, who remain bottom of the group without a win.
