Ligue 1 giants Paris Saint-Germain returned to winning ways in Group H with a 2-0 victory away to Istanbul Basaksehir.
After starting the campaign defeat against Manchester United, Thomas Tuchel opted a front four of Neymar, Kylian Mbappe, Angel di Maria and Moise Kean.
Despite dominating possession in the first half, PSG got the opening in the 64th minute courtesy of a strike from Moise Kean.
The striker on loan from Everton doubled the lead for PSG in the 79th minute to complete his brace on the night.
Chelsea claimed their first win in Group E after thrashing Krasnodar 4-0 at the Stadion FK Krasnodar.
The Blues were awarded a penalty after just 14 minutes, but Jorginho failed to convert after hitting the upright.
The Blues did eventually get the opening goal in the 37th minute, with Callum Hudson-Odoi firing home his first goal of the campaign.
Frank Lampard's men had to wait until the 76th minute for the next goal as Timo Werner converted from the penalty spot.
Fellow new signing Hakim Ziyech got in on the act three minutes later before Christian Pulisic wrapped up the result on 90 minutes.