The league leaders Bayern Munich were stunned 4-2 by the mid-table VfL Bochum in the Bundesliga on Saturday afternoon.
Robert Lewandowski got the Bavarians off the mark earlier on, but Christopher Antwi-Adjei and a penalty from Jurgen Locadia washed out the Pole's strike.
Cristian Gamboa and Gerrit Holtmann added to the visitors' woes and had the host on a comfortable pedestal at halftime as Lewandowski helped himself to a brace late in the tie.
As the table-toppers slipped, Bayer Leverkusen maintained the pressure from third spot following a 4-2 victory over VfB Stuttgart.
Moussa Diaby provided the lead late in the first half before Tiago Tomas responded, but Amine Adli and Florian Wirtz pulled the host further clear.
Tomas then got the relegation-threatened side a second before Patrik Schick had issued the host a fourth and subsequent victory.
Borussia Monchengladbach dented FC Augsburg's fight against the drop with a 3-2 victory at the Borussia-Park.
Goals from Kouadio Kone and Jonas Hofmann put the host ahead comfortably before Iago reduced matters only for Ramy Bensebaini to allay the home side's fears.
Alfed Finnbogason got the visitors a second at the death, but it was too little too late as Gladbach ended their three-match winless run in the league.
Greuther Furth won just for the third time this season after recording a 2-1 victory over Hertha Berlin out at the Stadion am Laubenweg.
The goals happened in the first 20 minutes through Branimir Hrgota, who also netted one from the penalty spot whilst Linus Gechter brought the visitors a consolation.
SC Freiburg maintained their top-four aspirations following a 1-1 draw against ninth-place Mainz 05 at the Europa-Park Stadion.
It was Mainz that showed the earlier intention and got the lead through Alexander Hack, but it was cancelled out after the break by Nils Petersen as it finished all square.
VfL Wolfsburg registered two wins on the bounce and continued their rise up the table following a 2-0 triumph away to Eintracht Frankfurt.
A penalty in the middle of the first half from Max Kruse and a last-gasp finish from Dodi Lukebakio put the visitors out of sight at the Deutsche Bank Park.
