On the back of their historical comeback against Paris Saint-Germain in the previous round, FC Barcelona travel to Juventus having never won an away match against the Italian giants.
UEFA Champions League
Teams: Juventus vs FC Barcelona
Date: 11 April 2017
Venue: Juventus Stadium
Time: 8:45pm
The two teams have met seven times so far, with their latest meeting coming in the 2014/15 Champions League final, when Barca beat Juve 3-1 to lift their fifth UCL trophy.
Overall, the Catalan giants have won three contests against their Italian counterparts, while Juve have won twice and two games ended in a draw.
The home side enter the game on the back of a 21-match unbeaten home run in the Champions League, while Barcelona lost two of their past three away games in the competition, and also went down away at Malaga on the weekend.
The Blaugrana, who qualified for this stage of the competition for a record 10th season, will have Ivan Rakitic and Sergio Busquets, who were both suspended against Malaga on the weekend, available for selection.
Gerard Pique, Rakitic and Neymar are one booking away from a suspension, however, while on Juve's side Juan Cuadrado needs to be careful.
Here's how the two teams will line up:
Juventus: Buffon, Alves, Bonucci, Chiellini, Sandro, Khedira, Pjanic, Cuadrado, Dybala, Mandzukic, Higuain.
Barcelona: Ter Stegen; Pique, Umtiti, Mathieu; Roberto, Mascherano, Rakitic; Iniesta; Messi, Neymar, Suarez.
Read: Has Ronaldo Admitted Defeat By Messi To This Trophy?
Who do you think will win this first leg? Have your say in the comments section below.