The international break is over, so if you haven't locked in your predictions, head to the Premier League Predictor now to be in with a chance to win great prizes!
There are two major matches in the Premier League this weekend, with the first game on Saturday being an absolute belter.
Liverpool will travel to Goodison Park to face Everton in the Merseyside derby, and will be looking to bounce back from their 7-2 humiliation against Aston Villa last time out.
The Toffees have been in sensational form since the start of the campaign, finding themselves top of the table after four games.
Later on Saturday, Manchester City will host Arsenal, with Pep Guardiola's side looking to regain their consistency. City have won one, drawn one and lost one of their first three games of the campaign, while the Gunners have won three out of four matches so far.
Those might be the two standout fixtures, but there are a number of other interesting ties to keep an eye out for.
Chelsea host Southampton at Stamford Bridge, while an under-pressure Ole Gunnar Solskjaer will take his struggling Manchester United side to Newcastle United, followed by another four fixtures on Sunday, and then two more matches on Monday night.
Check out the full round of fixtures below:
Everton vs Liverpool
Chelsea vs Southampton
Manchester City vs Arsenal
Newcastle United vs Manchester United
Sheffield United vs Fulham
Crystal Palace vs Brighton Hove Albion
Tottenham Hotspur vs West Ham United
Leicester City vs Aston Villa
West Bromwich Albion vs Burnley
Leeds United vs Wolverhampton Wanderers