The Premier Soccer League confirmed the fixtures for the Nedbank Cup round of 16 on Monday evening.
The first round action concluded on Sunday evening with the biggest upset in the competition, with Motsepe Foundation Championship side Milford FC eliminating Kaizer Chiefs.
Read: Milford 'Keeper Receives Special Praise After Chiefs Heroics
There was no problem for defending champions Orlando Pirates who thrashed third tie side Crystal Lake 6-0 at Mbombela Stadium.
The reigning champions have avoided DStv Premiership opposition for another round as they will take on Hungry Lions on home soil.
Sundowns will also enjoy a home encounter after being drawn against second tier Maritzburg United, who overcame Paarl United on Sunday.
Full Last 16 Draw:
Milford FC v Stellenbosch FC
Mamelodi Sundowns v Maritzburg United
Sekhukhune United v AmaZulu
Chippa United v FC Ravens
Orlando Pirates v Hungry Lions
University of Pretoria v Moroka Swallows
Richards Bay FC v SuperSport United
D' General v TS Galaxy
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