It's probably the most important round of fixtures in the competition as the teams' jostling for a semifinal spot intensifies with just two rounds of action to go.
TUT are the only team to have secured their spot in the semifinal thus far but face a tricky test in Pretoria when they host newcomers and surprise package CUT. CUT will need just one point to secure their spot in the playoffs.
Down the road, UP-Tuks welcome the unpredictable Fort Hare to the Tuks Stadium with the hope of bagging a win that will see them take a step closer to retaining their record of at least making the playoffs in every season.
Johannesburg will be split in two as UJ host cross-town rivals Wits at the Soweto Campus. Both sides are struggling at the moment and would be desperate for a win. The final match of the day sees a mighty clash in Mafikeng with NWU playing hosts to defending champions UWC.
The Cape side are currently in third place and are regaining their 2015 form while NWU have been the disappointment of the competition.
UJ v Wits (UJ Soweto Campus, 16.30)
It's desperate times for both teams as each has their own battle with form and consistency. UJ have flattered to deceive but have somehow managed to keep themselves in touch with the top four teams and would hope to return to winning ways at home.
Wits have had their preparations disrupted with their players and coaching staff having to juggle national university duty. It has led to them finding themselves at the bottom of the table without a victory. If there is a time to regain their form, this would be that fixture.
Prediction: The Johannesburg derby is always a tightly contested one and can go either way. However, based on form the home side will have the edge and should claim a one-goal victory.
UP-Tuks v UFH (Tuks Stadium, 18.30)
After securing their first victory of the competition, Fort Hare head into uncharted territories when they travel to Pretoria to play against two-time champions Tuks. This is the ideal fixture for Fort Hare to test themselves against the most consistent team in the history of the competition.
Tuks, on the other hand, are slowly finding their feet and this fixture has come at the perfect time for them to iron out all the niggles in their current system.
Prediction: Tuks have more to lose than just pride and even though Fort Hare will pose a threat, the home side should walk away with a comfortable two-goal win.
TUT v CUT (TUT Stadium, 18.30)
TUT have already secured their spot in the semifinals, however, they will want to ensure they finish top of the log with a game to spare. They may be tempted to rest some of their regular players but that could jeopardise their dominance.
CUT are hot on their heels, just two points behind and would be eyeing victory to jump into the top spot in their debut season. CUT have been nothing short of remarkable on attack and would be TUT's first proper test defensively.
Prediction: TUT has conceded fewer goals while CUT have scored more this season. This makes for a mouth-watering encounter and should end in an entertaining draw.
NWU-Mafikeng v UWC (Mafikeng Stadium, 19.00)
Three points and four places separate these teams on the log, so victory for the home side will see them move up the log and remain in contention for a semifinal spot. Much was expected from them on their return to the competition but they have flattered to deceive.
UWC have some momentum and confidence behind them as they are coming off their first victory of the competition. That victory was vital to their cause of retaining their title this season. Before that, they claimed four consecutive draws, showing they have been consistent.
Prediction: The Mafikeng crowd have remained faithful and will continue supporting their team through this rough patch. However, because of their momentum, the travelling UWC outfit seems likely to claim victory by the odd goal.