SuperSport United impressed their Last 16 tie by thumping Bayhill United 4-0 on Saturday afternoon.
Fagrie Lakay put in a fine individual showing by bagging a hat-trick, with Nqoi rounding off the scoring for the Pretoria-based outfit.
Ajax Cape Town secured their spot in the quarterfinals with a narrow 1-0 win over Zesco United in the Last 16 thanks to Leo Thethani's second-half strike.
Defending champions, Glendene United were sent packing, as they suffered a 2-0 defeat at the hands of Atlantic Nacional.
There was one major upset on the day, as Hellenic defeated AmaZulu 2-0, While, Swansea City made light work of Avendale Atletico, running out 4-0 winners to secure a last eight spot.
Bidvest Wits dispatched Harmony Sports Academy 3-0 to progress to the next round. Ikapa Sporting sent PP Langa crashing out, while Milano United came from behind to defeat Old Mutual Academy in extra-time.
SuperSport United v Swansea City
Ajax Cape Town v Hellenic
Ikapa Sporting v Atlantic Nacional
Bidvest Wits v Milano United