Bafana Bafana will have to do without the services of Tshepo Masilela and Kagisho Dikgacoi due to injury.
Kaizer Chiefs defender Masilela has had injury troubles throughout the season and is set to undergo knee surgery.
Dikgacoi took part in the English Championship promotion play-off final on Monday but had to be withdrawn with injury.
The midfielder reportedly tore calf muscle ligaments as his side beat Watford 1-0 to secure their place in the English Premier League next season.
Bafana coach Gordon Igesund has called up Ricardo Nunes as a replacement for Masilela, while no replacement has been named for Dikgacoi.
The national team is set to take on Lesotho in a friendly match before meeting Central African Republic (CAR) and Ethiopia in crunch 2014 World Cup qualifiers.