Bafana Bafana midfielders Kagisho Dikgacoi and Lerato Chabangu will miss Wednesday's Africa Cup of Nations clash with Angola through injury.
Dikgacoi has suffered a recurrence of a knee problem, while Chabangu has hurt his hamstring.
National coach Gordon Igesund expressed empathy for the duo.
"It is sad that the two players are not available against Angola," said Igesund.
"We have to work with all the players we have and the fit ones will have to do the job.
"KG and Ace are out of the game. They won't even be on the bench."
Meanwhile, Igesund revealed he has been working on the team's set-pieces following their goalless draw with Cape Verde in their Group A opener.
"As for the set-pieces we have worked on it and I hope we will use them perfectly this time around," said the former Moroka Swallows boss.