Thulani Serero came off after 85 minutes as he helped Ajax Amsterdam overcome Go Ahead Eagles 1-0 at De Adelaarshorst on Sunday afternoon.
Ajax moved back to the top of the table with the win, two points clear of Vitesse.
Anele Ngcongca lasted the full 90 minutes for RC Genk as they lost 2-1 to KAA Gent at the Cristal Arena, he also picked up a yellow card in the first half.
Ngcongca and Genk find themselves in sixth position in the Belgian Pro League, nine points adrift of fourth spot.