Manchester United visit PSV Eindhoven in their opening game of their 2015/16 Champions League campaign.
The fixture will see United new boy Memphis Depay return to his former club for the first time since leaving them in the summer.
PSV have faced the Red Devils before, in the group stage back in 2000/01 when they managed to beat the Red Devils 3-1 at home, but suffered defeat by the same margin in the return fixture at Old Trafford.
United are back in the UEFA Champions League after a season's exile, having finished fourth in the 2014/15 Premier League campaign. They then beat Club Brugge 7-1 on aggregate in last month's play-off round to secure their participation in the competition.
The Red Devils' away record against Dutch clubs is two wins, two draws and two losses.
PSV have lost their last three home games against Premier League teams. Their most recent success came when manager Phillip Cocu was still playing for the side – a 1-0 win over Arsenal in the 2006/07 Champions League round of 16.
In team news, Wayne Rooney will miss the match due to injury, while PSV will have a full-strength squad to choose from.
Here is how the teams will line up:
PSV: Zoet , Arias, Bruma, Moreno, Brenet, Hendrix, Propper, Guardado, Narsingh, De Jong, Lestienne
Manchester United: De Gea; Darmian, Smalling, Blind, Shaw; Schweinsteiger, Herrera; Young, Mata, Memphis; Martial
What's your prediction for this game? Have your say in the comments section below.