Jose Mourinho's Manchester United host Pep Guardiola's Manchester City at Old Trafford on Saturday afternoon – here are the starting line-ups.
The meeting will be the first time Portuguese tactician and the Spanish mastermind go head to head in the English top flight.
It is only the second time both Manchester clubs have gone into the fourth game of the season having won their opening three league fixtures.
Mourinho goes into this afternoon's tie as the first Red Devils boss to win his opening four games in charge of the Old Trafford club (including the Community Shield), while Guardiola is the first City manager to win his opening five games at the helm.
United will go into this tie full of confidence as they are unbeaten in their last three encounters against the Citizens. (Marshalls' odds: Man Utd to win at 2.3)
Guardiola heads into this tie with his own impressive record; the former FC Barcelona boss has lost only three matches to Mourinho in his coaching career, and the last happened back in 2012 in an El Clasico.
In terms of goals, England international Wayne Rooney goes into this fixture as the derby's top goalscorer, with 11 goals. (Marshalls' odds: Rooney to score at 2.65)
In team news, City will be without superstar Sergio Aguero, who is out due to suspension, and Vincent Kompany, who is still injured. United, however, have their full squad available for selection.
Here are the starting line-ups:
Manchester United: De Gea, Valencia, Bailly, Blind, Shaw, Fellaini, Pogba, Mkhitaryan, Rooney, Lingard, Ibrahimovic
Manchester City: Bravo, Sagna, Otamendi, Stones, Kolarov, Fernandinho, De Bruyne, Silva (C), Sterling, Nolito, Iheanacho
Betting Odds
Marshalls' odds for outright winner after 90 minutes
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