The Germans beat the Gunners at the Emirates during the last round of group stage matches, and even with Wilshere, the London side would have faced an uphill task to win in Westphalia.
They did manage to subdue Liverpool without Wilshere at the weekend, but Dortmund are on another level to the Reds, and Gunners boss Arsene Wenger would ideally have had a full-strength squad to pick from.
Unfortunately, England international Wilshere rolled his ankle in training last Thursday, and will not recover in time for the date in Dortmund.
The only good news is that the injury is not to Wilshere’s troublesome right-ankle, which has hampered his development to the tune of nearly two years out of the game.
Gunners fans still wince every time Wilshere takes a knock to his right foot.
And Wenger has recently gone on record to say Wilshere is not out of the woods yet, because the way he gingerly protects his injury prone right foot from further damage makes his left foot susceptible to harm due to over compensation.
In that way, Wilshere will not be forced to enter a scrap for European survival when he is healed from his latest brush with foot problems.