On-loan liverpool midfielder, Luis Alberto, scored the only goal of the game as nine-man Malaga defeated Athletic Bilbao 1-0 in the opening league clash.
The home side had Duda and Antunes sent off in the space of two minutes in the closing stages of the game but managed to hold for the win.
Lucas Orban scored in the 88th minute to cancel out Aleix Vidal's first half striker, as Sevilla and Valencia played out to a 1-1 draw in their season opener on Saturday evening.
Deportivo La Coruna's return to the Spanish top-flight did not get off to a good start, after they were beaten 2-1 by Granada at Estadio Nuevo on Saturday evening.
Ivan Cavaleiro opened the scoring for Deportivo in the 21st minute, but strikes from Ruben Rochina and Jean-Sylvain Babin secured a opening day win for Granada.