The Bay Arena has become a daunting stronghold for the Bundesliga side of late, with hardly any teams escaping with even a smidgen of joy on their Champions League visits.
But English champions United made a mockery of Leverkusen’s status as one of the form teams in Germany, putting them to the sword with five unanswered goals.
When Moyes first arrived at United he came with a message of patience, veering on doom and gloom.
After a run of poor early results he warned of more defeats to come, and as he began his first Champions League campaign in charge he even cautioned that a group stage exit was on the cards.
But it seems that all it took was one emphatic European result for Moyes to banish the negativity, and now he says that even better days are on the Red Devils’ horizon.
"It was one of my best days as Manchester United manager but the best days are still to come,” Moyes said after the game.
“There will be better days to come. We won well, we played well, with some outstanding performances.
“To come to Germany and win 5-0, and they have a great record here in Leverkusen, puts it in perspective as well."
And perhaps even more exciting than Moyes’ newfound positivity is his eventual understanding of Shinji Kagawa’s worth.
The Japanese midfielder was pivotal to United’s win, and linked up with talisman Wayne Rooney impressively.
The United faithful have been crying for Moyes to acknowledge Kagawa’s ability, and after the playmaker’s star showing last night, the manager has finally done so.
"I said at the start of the season that sometimes Wayne might have to play up front and Shinji in behind when Robin [van Persie] is injured,” Moyes said.
“I thought Shinji played really well tonight, he was excellent, but he has been excellent when he's played off the left as well. We have some really good players.”