Goals from Raheem Sterling and Daniel Sturridge secured a 2-1 win for Liverpool over Southampton at Anfield.
Nathaniel Clyne looked to have snatch a point for the Saints, but Sturridge popped to secure a opening day win for Brendan Rodgers.
The game off to a slow start, with neither side managing to create any chances in the opening 20 minutes.
However, the home side took the lead in the 23rd minute through Raheem Sterling's composed finish, after being played in by Jordan Henderson.
Mignolet was called into action midway through the first half, as he almost misjudged the flight of James Ward-Prowse's free-kick but he managed to parry the effort away for a corner.
Morgan Schneiderlin came close to leveling matters just before the halftime breakk, but his curling effort from 20-yards out was tipped over the bar by Mignolet.
Southampton equalised 10 minutes after the restart, Tadic's neat flick played in Nathaniel Clyne, who rifled the ball past Mignolet.
Sean Davis should have given the visitors the lead in the 63rd minute, Ward-Prowse picked teed up the un-marked midfielder on the edge of the area, but he could fire an effort straight at Mignolet.
Sturridge then put the home side infront with 10 minutes to play with clinical finish from six yards out, after Sterling's header had teed him up.
Southampton almost leveled matters once again in the 88th minute, as Mignolet tipped Schneiderlin's effort onto the crossbar befoe Shane Long managed to head wide with the goal at his mercy.