The biggest tie of the round will see Arsenal begin their tournament with a clash against Southampton at the Emirates stadium.
Defending League Cup champions, Manchester City, will host championship outfit Sheffield Wednesday at the Etihad.
Chelsea hosts championship side Bolton Wanderers, while Liverpool will lock horns with Middlesbrough at Anfield.
There are another four all-Premier League ties, with West Bromwich taking on Hull City, Sunderland hosting Stoke City, while Swansea will hosts Roberto Martinez's Everton, and Crystal Palace take on Newcastle United.
The rest of the third round draw:
Leyton Orient v Sheffield United
Cardiff City v AFC Bournemouth
Derby County v Reading
MK Dons v Bradford City
Burton Albion v Brighton and Hove Albion
Shrewsbury Town v Norwich City
Tottenham Hotspur v Nottingham Forest