Inter Milan missed their opportunity to move above Lazio into third place on the Serie A table as basement-dwellers Siena beat them 3-1.
Inter have failed to claim a single win on their travels since November last year but would have expected better against such lowly opposition.
Home debutant Innocent Emeghara stunned the Nerazzurri with a 21st minute goal but Antonio Cassano had the visitors level within a minute.
However, they had no reply when Alessio Sestu restored the lead only a matter of minutes later.
Cristian Chivu saw red early in the second half and Inter never recovered as Alessandro Rosina converted the resulting penalty.
Siena took the game to their hosts from the moment the whistle blew and Emeghara created a chance for Rosina who fired wide.
The Nerazzurri had chances of their own with keeper Gianluca Pegolo keeping out efforts from Fredy Guarin and Juan Jesus.
A swift counter attack was launched by Siena and Matteo Rubin slammed a ball across goal which Emeghara turned home.
The response from the San Siro outfit was immediate as Yuto Nagatomo supplied Cassano who fired into the corner.
The scores were not level for long as Sestu evaded the attentions of the opposition and rifled the ball into the back of the net from the edge of the area.
A comeback looked to be on the cards for the Italian giants Inter but Chivu made that infinitely harder after scything down Emeghara in the box.
Rosina made no mistake with his spot kick to give the hosts a dream lead.
Goal scorers Sestu and Rosina looked to add to their tally’s but could not cap off swift counter attacking moves put together by their team.
Meanwhile, Lazio’s title hopes were dealt another blow as they fell to a 3-2 loss that that lifted Genoa out of the Serie A relegation zone.
Genoa’s new head coach Davide Ballardini was delighted as his team took a two-goal lead thanks to goals from Marco Borriello and Andrea Bertolacci.
Sergio Floccari and Stefano Mauri equalised for visitors Lazio before a last-gasp goal from debutant Marco Rigoni settled the encounter.
In the late kick-off on the day, Mario Balotelli made a dream start to life with AC Milan as his double took them to a 2-1 win over Udinese. The former Manchester City man lashed a superb strike in at the near post before tucking away a controversial penalty with the last kick of the game.
Two struggling teams met as Atalanta triumphed 2-1 over Palermo.
Second-half goals from Carlos Carmona and German Denis put Atalanta in front and Nelson's late goal proved a mere consolation.
A topsy-turvy encounter between Bologna and Pescara ended in a win for the former as they edged their opponents 3-2.
Pescara dropped into the Serie A relegation zone despite taking the lead on two separate occasions.
Pescara scored from the penalty spot Vladimir Weiss whilst Alessandro Diamanti equalised, alos from 12 yards.
Gaetano D'Agostino converted a second penalty for Pescara but Alberto Gilardino and Panagiotis Kone wrapped up victory for the visitors.
Fiorentina righted the ship somewhat as they recorded a convincing 2-0 victory over Parma at the Stadio Artemio Franchi.
It was a first win in five for Fiorentina who had Luca Toni and Stevan Jovetic to thank for their goals.