It is a day of milestones for Spanish football, as the most successful national team of all time takes on Uruguay in Qatar.
Spain's fearless defender Carles Puyol could win his 100th cap for La Furia Roja if he plays against the South American champions.
Vicente Del Bosque will equal the record for the most matches as coach of the Spanish national team, drawing level with the 68 games as Spain’s coach set by Hungarian-born former Spain boss Ladislao Kubala.
And all of Chelsea defender Cesar Azpilicueta, Malaga’s highly-rated attacking midfielder Isco and Mario Suarez of Atletico Madrid could make their international debuts at Doha's Khalifa International Stadium.
It is a new-look Spain side, partly because of the debutants, as well as the absence of out-of-form Fernando Torres.
But there are also only two Real Madrid players in the squad- Sergio Ramos and Alvaro Arbeloa- because of injuries to regular skipper Iker Casillas and Xabi Alonso.
Ahead of the game, Del Bosque has been forced onto the back foot after complaints of a pro-Barcelona bias, considering the fact that there are nine Barca players in the squad.
"I am a madridista and I have never hidden that," he said.
"Barca has the biggest number of players because the national team is a reflection of the clubs. But there are players from many teams. The mixture of all marks the style of the team and the image of Spain."