The draw for the FA Cup quarterfinal fixtures was made on Saturday evening.
All of the big sides avoided each other in the last eight draw, which could set up a couple entertaining semi-final affairs.
Manchester United defeated Huddersfield Town on Saturday evening, but will now hosts Brighton and Hove Albion.
The biggest tie of the round will see Chelsea travel to the King Power Stadium to face Leicester City.
Manchester City, who only play on Monday night, could face Southampton if they beat Wigan Athletic.
Sheffield Wednesday/Swansea City vs Rochdale or Tottenham Hotspur
Manchester United vs Brighton & Hove Albion
Leicester City vs Chelsea
Wigan Athletic/Manchester City vs Southampton