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The 2020/21 season will get underway this Saturday, 12 September, with defending champions Liverpool hosting newly promoted Leeds United in the opening game.
Arsenal will also take on a promoted side when they travel to Craven Cottage to face Fulham.
One of the games to look out for on the opening weekend will certainly be Jose Mourinho's Tottenham Hotspur facing off against Carlo Ancelotti's Everton in London.
Both Manchester clubs will not be in action in the first game week, but Frank Lampard's new-look Chelsea will head to Brighton on Monday, 14 September.
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Check out the full list of opening fixtures below:
Saturday 12 September
- Crystal Palace vs Southampton
- Fulham vs Arsenal
- Liverpool vs Leeds United
- West Ham United vs Newcastle United
Sunday 13 September
- Tottenham Hotspur vs Everton
- West Bromwich Albion vs Leicester City
Monday 14 September
- Brighton vs Chelsea
- Sheffield United vs Wolverhampton