Pitso Mosimane's Al Ahly claimed the bragging rights in the Cairo Derby after edging Zamalek 2-1 on Sunday evening.
Mosimane made two changes from the narrow win over Simba in the CAF Champions League, with shot-stopper Ali Lotfi and Taher Mohamed both getting rare starts.
The Red Devils were all over Zamalek in the opening exchanges and Mohamed Sherif eventually broke the deadlock on 21 minutes with a strike into the bottom corner after he was picked out by Ayman Ashraf from a set-piece situation.
Shikabala levelled matters for the White Knights - just as he did in the CAF Champions League final - with a superb effort that left Lofti with no chance just after the half-hour mark.
However, Sherif restored the lead for Al Ahly three minutes later with a screamer from outside the box to complete his brace and put his side in control at the break.
Zamalek were fired up after the break, which resulted in the side winning a penalty by the Video Assistant Referee (VAR) just before the hour-mark after Lotfi fouled Seifeddine Jaziri inside the box.
Mohmoud Alaa stepped up take the spot-kick but his effort was saved by Lotfi, who redeemed himself and preserved the lead for Al Ahly.
Mosimane responded with e a double change in the last quarter of an hour, as Marwan Mohsen came on for two-goal hero Sherif while Kahraba replaced Taher Mohamed,
In the end, the Red Devils held on to claim the three points that moved them up to second on the log, three points behind their rivals Zamalek, who have played three games more.
Check out the top 20 of CAF's 21st century club rankings, including Al Ahly, below: